Unfortunately, you can search code by file extension and phrase, and you can use advanced search to search for repository descriptions filtering by stars, but I don't believe you can do both at once.
For instance, searching for "flask" and limiting the results to >1000 stars returns only the 27 repositories with a matching description[0], but the code search returns over 4 million results, ignoring the stars parameter[1].
How would you build the search results UI for a grouped query like this? If one repository has 10k stars and has 1000 files with matching strings, should the first 1000 results be from the same repository?