[jefftk]

    single tax receipt (donating to one org instead of 3-4)

GiveWell offers this as well: https://secure.givewell.org/

You can donate to GiveWell for distribution to their to charities, and you can either choose the breakdown or ask them to allocate it as they think best.

[tmacaulay]

That's true. You can donate to GiveWell's top charities directly through GiveWell. For many donors, especially those who only want to donate to proven charities with a good track record, this is a great choice.

With our Global Health and Development Fund, we hope to also make small, seed grants to promising new initiatives, to help them build evidence to support their program, or to replicate a promising intervention in a new geographic region, to figure out if the program can scale. Many of these donation opportunities are small, and individual donors won't necessarily hear about them. With Elie managing this fund, we hope to be able to quickly fund promising new projects, so they spend less time on PR and fundraising, and more time doing good work.

[colophonemes]

Good point — a nice feature but not a point of differentiation from Givewell's donation page... I think the others still stand – in general you gain additional flexibility with the Funds without compromising effectiveness.