[GeneralMaximus]

I've dabbled a bit in both Django and Pylons, and I've found working with Pylons is much easier than working with Django. Django has more "magic", which freaks me out. Pylons, on the other hand, mostly consists of glue code to tie different modules together and the Pylons book goes to great lengths to explain how this glue code works.

Setting any one of them for development is easy: just install them in a virtualenv using pip. Can't say how they fare in production setups. I'm not there yet :p