[said]

I wonder whether this variant is similar to APOE E4 allele—which significantly increases one's risk of Alzheimer's—in that its affect can be minimized by lifestyle changes.

In men, APOE E4's disadvantages can be almost completely eliminated (compared to APOE E3) by regularly exercising and completely abstaining from alcohol.

[telarson]

I haven't seen many research papers that claim abstaining from alcohol helps reduce ALZ risk in E4 carriers. Care to share?

[alakin]

As I understand this only works for E3/E4 variants. Not homozygous E4/E4.