[LnxPrgr3]

I am not an expert, but since no one has answered I'll give what I know and hope somebody corrects me if I'm terribly wrong.

Substrate: the thing that's supposed to bind to something normally. SERT: transporter that pulls serotonin out of synapses back into the neuron that put them there in the first place. DAT: similar, but for dopamine and to some degree norepinephrine. Competitive inhibition: inhibition depends on whether the intended substrate for a site is present—the drug and substrate interfere with each other competitively. Non-competitive inhibition: the drug inhibits the function of a site even if the intended substrate is already bound to it.

As to how any of this explains or refutes claims ibogaine short-circuits withdrawal, I dunno. Feels a bit like trying to explain JavaScript in terms of quantum mechanics. Both these papers are evaluating the drug's interaction with neurons, not the drug's effect or non-effect on addiction.