My own experience, as well as anecdotes from a lot of runners that I know, all confirm that running is very hard on the knees. Whenever I've had knee issues, the exercise that I have to cut out in order to make them go away is always running.
Or are you objecting to the "on pavement" bit? I don't really know whether that matters, I live in a city so all of my running is on pavement.
The studies [1] and [2] found no evidence of any adverse effects, rather the contrary (lower incidence of knee osteoarthritis in the running group). One possible explanation is that the runners were less likely to put on weight over the years, leading to lower day-to-day stresses on the knees.
[1] Eliza Chakravarty et al. "Long distance running and knee osteoarthritis: A prospective study," American Journal of Preventive Medicine, 2008, 35(2), 133-138
[2] David Felson et al., "Effects of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: The Framingham Study," Arthritis & Rheumatism, 2007, 57(1), 6-12
Thanks to the other poster for linking some studies. My comment draws from discussion with a leading researcher in the area as well as background awareness of research developments, but I don't know studies off the top of my head without doing a search.
The question of pavement vs soft surfaces is AFAIK open from an injury standpoint. Many people would expect that soft surfaces lower injury rates but I don't think we have evidence to support that.
There's also a difference, which may play a role, between short-term knee problems like runner's knee and underlying damage like osteoarthritis.
What follows is just my opinion/interpretation, but might be helpful. Knees in running are a bit like bearings in a car wheel. They don't generally go bad on their own (unless they are overloaded when not ready), but instead because of imbalanced forces around them, like mis-aligned wheels or tire tread wear. The knee has a lot of outside forces acting on it, mainly from the quadriceps and the IT bands, and if these forces aren't in harmony, they will pull on the knee and affect the way it tracks/moves. Since the knee has to move thousands of times over the course of a single run, a small imbalance can add up and cause injury. So a lot of times the fix lies in stretching or strengthening the quads and IT bands (e.g. I find sometimes that a knot in my quads can cause knee problems in running that go away soon once the knot is worked out).
My own experience, as well as anecdotes from a lot of runners that I know, all confirm that running is very hard on the knees. Whenever I've had knee issues, the exercise that I have to cut out in order to make them go away is always running.
Or are you objecting to the "on pavement" bit? I don't really know whether that matters, I live in a city so all of my running is on pavement.