[OrthoMetaPara]

In addition to mitigating errors in copying as you've highlighted, there is also the possibility that some stretch of bases in your message would have some deleterious effect on the organism. Thus, you would need to include some kind of redundancy into your code so that a bit could be represented in several different ways. The computer that encoded the message could then try to optimize the message so that it would be maximally amenable to storage.