[jmkd]

One thing often overlooked about work interruptions: interrupting one person's flow is usually to aid another's.

So as others have suggested the response can be prioritised according to importance and urgency.

While flow is critical for productive work, it should be directed to the highest priority tasks.

[cmdrfred]

In construction we have a phrase "a dime holding up a dollar". It is up to you to decide if you are a dime or a dollar in each situation.