[theaustinseven]

I personally haven't found any quite as good as the Bike Shed(http://bikeshed.fm/). It does often focus on Ruby, but overall the types of problems they cover are not limited to Ruby in scope. I mainly like it because I get to hear some developers significantly more experienced than myself talk about how they solved certain problems.

[sjellis]

I would second this. For me, the fact that they often talk about Ruby helps me understand more easily, but I really listen because I like the hosts and it's interesting to hear how people in a successful consultancy and a SaaS company work.

I've also started listening to Go Time: http://gotime.fm. The hosts are good, and deeply involved in the Go community, so they always get really excellent guests.