[endentru]

I think hrodriguez meant that it was the shock of going from a ~3 year low-sugar diet to a 40-tablespoon-per-day diet that was responsible for the sudden influx of negative effects, one that might not have been seen if he gradually eased into the high sugar diet.

[hrodriguez]

Exactly. For example, I don't consume alcohol. When I do so on the rare occasion, just a little hits me very hard. Regular drinkers don't have this issue. I would never think of going from zero alcohol to consuming a bottle of vodka every day.

I also enjoy a pretty healthy diet/lifestyle - low-salt, low-fat, fruits, veggies, plenty of fiber, regular exercise... I find that my body reacts very badly if I "treat" myself and indulge throughout the day in whatever everyone else consumes so freely. No such issue if it's just a single meal.

I need to taper in (ie, the Holidays are a good example). High salt, high-fat meals are especially hard hitting. I can counter this with lots more water, fiber for example. I also know that if I remained on these richer diets, eventually my body wouldn't react so strongly but I would also need to make other dietary changes. Damon Gameau admits he did not make other changes to his diet.

The experiment was a non-stop, high-dose, sugar binge (40 tsp is incredibly high) that went from 0-100 mph in a microsecond.

[milesvp]

I imagine this to be a problem as well. One of the things I've been starting to hypothesize a lot about is gut biome effects on diet and nutrition. If you just up and change your overnight, your gut flora doesn't have time to evolve to the new conditions. I'm also starting to suspect, based on the popularity of month long elimination diets, that a month is the amount of time it takes for gut flora to significantly change, and that at the least you'd want at least that much ramp up time.