For example, in C the assignment operator evaluates to the value of the right-hand side expression (so `int x = (y = 2);` initializes `x` to 2). But in Rust, the assignment operator always evaluates to `()` (a.k.a. "unit", the empty tuple), and trust me, this is how you want the language to work in the presence of pervasive move semantics and single ownership. Furthermore, nothing in Rust is "truthy": if-expressions accept a boolean and nothing else (this is also, IMO, exactly what you want in every language, but I'm sure others will disagree :P ). So `if x = 2 {` is a compiler error in Rust because `()` can't be coerced to a boolean (to say nothing of the fact that this reassignment would probably be a compiler error anyway because most variables in Rust are immutable). This doesn't require any acrobatics, it's just the natural fallout of how the rest of the language works.
That's a cure worse than the disease. If I faced a false choice between = as an assignment operator or else accepting syntax that distinguishes statements and expressions, I'd just take the = operator.
No, that's just because the example I used was Rust. In Ruby it would be `if user = User.find(..)` and the same goes for Go and plenty of other languages.