I'm based in the EU (until Brexit anyway) and often do calls with mainland Europe. Never had that problem. Seen a high CPU warning a couple of times but it goes away. Overall I'm a fan. I have friends who use it for virtual conferences even.
I use the free version out of the box to onboard new people (mostly independent coaches/consultants from around the world) as partners - see https://www.agendashift.com/partners to get a feel of geographic coverage