[habosa]

Almost every Android app that includes the most common dependencies (Android support lib, Google Play services, etc) will end up being multi-dex.

This used to be a massive pain but lately the Android Studio / gradle multidex tooling has gotten so good that I don't notice anymore.

[krschultz]

You still incur a startup penalty with multi-dex, it takes noticeably longer than a single dex, even if you are only marginally into that 2nd dex.