Well, what's problematic is democracy. Representative government doesn't protect against this sort of data-driven populism. If people can be manipulated so efficiently, how can democracy be workable?
One answer: restricting the vote to people who have skin in the game. If you have to personally pay for your favored policy you might consider it more carefully.
Not only are they easier to manipulate - they have a conflict of interest when they (for instance) demand that the government pay them money when they don't pay taxes.
That seems a good start. But maybe that's game-able too. If you're dealing with an AI (or proto-AI, at least) that understands you better than you do yourself, you're pwned. So then you need your own AI, to filter input and flag exploits. Rather like anti-malware, for your mind.
The idea is to create a human programming language to encode activities for learning/practicing principles found in the book Nonviolent Communication and publish that before publishing the language as a way to protect oneself.