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There's also an environmental aspect at play. Italians drink a lot of wine but I have never seen a drunk Italian, not once.

The English, on the other hand, get completely hammered.

The Romans had trouble instilling their calm Mediterranean cafe culture in the gray and frigid binge-drinking north. It's an environmentally inspired culture difference that goes back thousands of years, so it's hard to draw a conclusion about drinking and humans as a whole.