I once switched to DVORAK, but then I noticed I couldn't easily do ctrl-z, ctrl-x, ctrl-c and ctrl-v, ctrl-s, ctrl-a with my left hand, so I switched back. (Maybe some combinations are possible, too lazy to find out ;))
This is also killing me, I've switched to DVORAK a few months ago and I'm up to speed, but missing these shortcuts can be pretty painful at times, especially with cut, copy and paste.
I have adjusted to doing Ctrl-Insert, Shift-Insert, Shift-Delete, I just have to constantly refrain from doing Shift-Delete when handling files, but it's still not as comfy as the QWERTY shortcut positioning.
Overall I'd say it's still worth it, the positioning of the punctuation marks is better and my fingers travel a lot less.
I have adjusted to doing Ctrl-Insert, Shift-Insert, Shift-Delete, I just have to constantly refrain from doing Shift-Delete when handling files, but it's still not as comfy as the QWERTY shortcut positioning.
Overall I'd say it's still worth it, the positioning of the punctuation marks is better and my fingers travel a lot less.