I wish I could have read more than the abstract, but maybe this [1] ... I would especially like to know what do they mean by "Unfortunately, the available data suggest that the rate of reversibility will be slow at the community level"
> In hospitals, both modelling and analysis of
the correlations between antibiotic resistance and variation
in antibiotic use show that alterations in antibiotic
use can cause rapid changes (in the order of days
to months) in the frequency of resistance. By contrast,
when the fitness cost of resistance is the main driving
force behind its reversal, the rate of change is expected to
be much slower (months to years).
I think what that means is that hospitals are able to create more selective pressure by rotating through different kinds of antibiotics.
> In hospitals, both modelling and analysis of the correlations between antibiotic resistance and variation in antibiotic use show that alterations in antibiotic use can cause rapid changes (in the order of days to months) in the frequency of resistance. By contrast, when the fitness cost of resistance is the main driving force behind its reversal, the rate of change is expected to be much slower (months to years).
I think what that means is that hospitals are able to create more selective pressure by rotating through different kinds of antibiotics.