[pharrlax]

LSD is one of the safest drugs around, in terms of health effects, at recreational doses (let alone at microdoses).

Unless there are some mystery side effects I'm not aware of, I'm not sure how your analogy makes any sense.

[hawkice]

A single dose of LSD may be able to permanently change your personality [1], which is, as the abstract points out, essentially unheard of. This is perhaps one of the most psychoactive chemicals known to humankind, which certainly has long-lasting effects.

That would be the mystery side effect you aren't aware of.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537171/