[blindhippo]

My personal approach is to present myself as an individual with a large amount of skill and experience working in a specific programming discipline (e.g. web applications). I present a short list of the core tech I have experience with, ones I'm comfortable answering interview questions in. I do not list every tech I've used - that list would be half a page long and do no one any good.

I describe the projects I've worked on, what the problems challenges were, and how my work helped solve them. The format I use tends to work itself out as a simple narrative outline, and I tailor every resume to be the most relevant to the position I'm applying to, and I submit a cover letter specific to the job. This isn't "gaming" the process, this is doing your homework on the company/position and selling yourself as a viable candidate. If I'm weak in a desired skill, I call it out in the letter and demonstrate my past experience as an example of how I can learn new technologies quickly (something vital for any programmer, IMHO).

That said, after a certain level of experience, relying on your resume to get you in the door isn't going to get you the job you want in most cases. You want to meet people directly and apply via recommendations or requests. Direct contact with peers working at the company you want to apply to matters a lot. Even communication with a recruiter is better then blind submitting to a job post.