[amjaeger]

Uber's "Otto" is already making autonomous trucks.

You're describing a traveling salesman problem - which there are plenty of working solutions (even if we don't know the best solution yet) And then an autonomous forklift problem - there are a few companies already making them. And packaging + placement can simplify any issues if they exist. Maybe throw in a robotic arm in the back of the truck for good measure.

Autonomously refilling a tank of gas could be a fun problem to solve. But full service stations already exist. Those should be able to stand in until there is a better solution, such as Tesla's battery swap stations but for trucks.

Now, without a human driver the trucks can be working 24/7. No need for sleep. Which might be worth it even if a human accompanies the truck and just sleeps in a back section. Also who wants to pay a person to drive a truck, when the truck can drive itself for free?