These are good alternatives until you are building a large house, where you have, say 300 switch legs, 90 dimmers, 75 keypads, etc. You start to realize Lutron is your friend.
I'd believe it. Do you have pointers to anything more with experience about this? What falls down?
(That said, I don't see needing to go there. My house has, from a quick mental count, about 52 total switches. I'm probably missing a few, but that's the right ballpark. A 300 switch house sounds like a monster.)
Lutron RA2 systems are very reliable. I centrally (home-run) wire all of the switches for future upgradeability, but I have very little issue with their systems. They can run wirelessly, but if its new construction, must also wire.
Unless the application is a Star Wars level system, I recommend RA2, otherwise Lutron Homeworks can be your best friend.
(That said, I don't see needing to go there. My house has, from a quick mental count, about 52 total switches. I'm probably missing a few, but that's the right ballpark. A 300 switch house sounds like a monster.)