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by kingjacob 3483 days ago
It is. But technically they are correct.

If you just handed out phage freely, as you do abx, bacteria will "eventually" evolve resistance to phage....at a 2-3 orders slower rate, but it will eventually happen.

Of course, the solution is easy, you don't develop a phage therapy like you would an antibiotic, but rather like a constantly updating flu vaccine.

1 comments

The 'therapy' might not be handing out pre-grown phages, but literally doing the labwork to isolate and grow phages right in the hospital for each patient.

This was how phage therapy was originally developed, and it's still being done that in some surprising places like Georgia [1]. They have phage 'banks' for common bacterial species, and it's not effective, they end up taking bacterial samples from each patient and isolating more phages.

[1] https://www.phagetherapycenter.com/pii/PatientServlet?comman...