I'm a big fan of Flask, but if OP has never used a web framework before, personally I'd recommend starting with Django, because there are more resources out there. Flask is great if you know what you're doing and have the experience to architect a larger project, but Django is (more) batteries included and more opinionated about how things should fit together. As a beginner, it makes a lot of the tough decisions for you, and starting out that's a good thing. In Flask, it's easier to get to "Hello World." In Django, it's easier to get to "Working Web Application."