[fatdog]

There is related work on dementia as well, wish I could find it. Something to do with increasing dietary ketones (using oils) to make up for glucose processing issues in people who were long term pre-diabetic.

It was a dinner conversation, where a guy was reasoning that some degenerative and autoimmune diseases were related to tissue starvation as a result of inhibited glucose processing, and he was using ketones (with some perceived success) to treat symptoms of his own auto-immune disorder.

It's not evidence or confirmation in any way, but for any biohackers out there it's something to play with.

[spangry]

Just to provide the counter-point: also possible that increased protein metabolism and synthesis (the defining feature of ketogenic diets) increases the likely hood of long -lived prions: proteins that fold abnormally, which can be learned by other newly synthesised proteins leading to these "mutant proteins" forming plaques on the brain (which is now burning protein for energy due to depletion of glucose).

And there might be a runaway/tipping point somewhere here: some amino acids have acidic metabolites and also need to capture hydrogen ions from red blood cells to metabolise/synthesise protein. Some of these metabolites also cause acetone build up in body, which starts to be expelled via lungs.

So combo of high rates of protein synthesis, abnormal blood plasma pH balance and increases cell oxidisation and anion gap == greater rate of prion formation and survival.

This is just a personal hypothesis, no real evidence to back it up. Just suggesting caution should be exercised here. PD is a horrible disease, I wouldn't wish it on my worst enemy.

[fatdog]

It's important to discuss. There is a lot of stuff out there that screams snakeoil about MCT and coconut oil products, and it can have the effect of both discouraging legit research and duping the dupable.

If there were only a way to test medical hypothesis like hacking on code. Maybe a platform to crowdsource data for experiments then control for factors and double blind it.

[fatdog]

not to reply to own thread on theme, but want to also add ketogenic diet was also used for treating "epilepsy," now known as a general class of seizure disorders, which are related to many issues, among them brain lesions. I have zero medical background, and if you are searching on this stuff, my point is that beyond the political stuff, there is something up with sugar.