[WhitneyLand]

I'm not aware of these drugs directly causing the death of anyone (excluding someone driving on the freeway after taking them). Do you have an example of a fatality?

As for the other unpleasant effects it's true these can happen temporarily. I know some people anecdotally believe negative effects can be permanent, but I'm not aware of any research supporting cause and effect.

Now weigh the risks above with the possible reward. Near death comfort (while important) is only one application. For example anxiety and OCD are life crippling for so many people, and research suggest psychedelics might offer one of the best treatments yet.

The potential benefits to society are so great, the research must continue. I also see no reason you could not help out with some empirical study.

[echlebek]

I found a reference to LSD directly killing someone. They injected 320,000 ug intravenously!

https://www.erowid.org/ask/ask.php?ID=220

[hvidgaard]

To put that in perspective, the "typical" dosis according to wikipedia is ~200ug.

For comparison, if you drink 10L of water, 200 espresso shots, or 600ml of 40% alcohol in one setting, you are likely to die.

[blubb-fish]

Let's assume a psychoactive vodka dose of 10ml and a typical dose of 100ug LSD:

Then the respective vodka dose would be 10ml x (320'000ug / 100ug) = 10ml x 3200 = 32000ml = 32 l

Obviously vodka would be deadly at an amount way below 32l.

[Taek]

(for the unfamiliar, a recreational dose is typically between 70 and 200ug. 200-400 is a heavy dose, and 400+ will leave you incoherent for many hours.)