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I think you may misunderstand me as I wasn't clear

"Cellular level investigations are obviously important but getting a wire in somewhere is not going to happen at a level this small It does happen, there exist small electrode array implants that can be placed in neural tissue to both induce (for example, cause sensations that one can feel) and read-out activity. Such implants are in fact used in some human subjects (there are issues such as development of scar-tissue however)."

What I mean - in a human subject the placement of any implant is not going to be guided by anything approaching a cellular level of imaging resolution. It will mostly use conventional radiological image guidance to get close and then measure electrical signals once close. Or is this in fact what you are saying?

Sorry about my formatting - phone.