I'm not a fan either but Galaxy S Edge is quite popular and I think it has sides that are far more prone to unintended interactions. Yet, I never hear of anyone having that issue.
I have the Edge and frankly i hate this gimmick precisely for that reason. Never used cases on my previous phones, but will be looking for one this time. Love the extra large battery though, so it's not all bad.
I am having that issue with Samsung Galaxy S7 edge. Whenever the screen is unresponsive it is because you are accidentally touching some part of the screen with your palm.
I have an S6 edge and I regret that purchase pretty much every day, specifically because i can't pick up the phone without causing a touch event somehow.
Love the design though, so if they just made the side edges touch-free I would be happy.