I've got a Sharp Aquos Crystal. If I use it without a case, it will frequently register touch events on the edges of the screen just from holding it. There's no way to hold it that will prevent this.
That's all really a software issue. The iPad Mini allows you to hold it even with your thumb touching the screen and it works perfectly fine, for example.
If google integrated that kind of thumb/holding hand rejetection to android (since most android manufacturers seem too incompetent to do it themselves) we could absolutely see an era of bezel-less devices that works fine.