I wonder if it will be able to cope with case-sensitive filesystems? I still haven't got to play one on my Mac because they've never supported case-sensitivity.
I created a separate case insensitive partition on my MBP to deal with that issue. For things that really, really wanted to use the main partition, I moved their content to it and created a symbolic link for things like ~/Library/Steam that points to the other partition. Was a very effective solution.
Playing Civ 5 here on Antergos, works flawlessly, very nice experience. Having the successor for Linux as well would be just awesome. However, it's not totally clear whether it will be ported… cf. https://www.reddit.com/r/linux_gaming/comments/55vuci/civili...