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by kvb
3535 days ago
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I like the way Scott Alexander frames the effect size. This is from the conclusion the blog post you link: An important point I want to start the conclusion section
with: no matter what else you believe, antidepressants are
not literally ineffective. Even the most critical study –
Kirsch 2008 – finds antidepressants to outperform placebo
with p < .0001 significance. An equally important point:
everyone except those two Scandinavian guys with the long
names agree that, if you count the placebo effect,
antidepressants are extremely impressive. The difference
between a person who gets an antidepressant and a person
who gets no treatment at all is like night and day. The
debate takes place within the bounds set by those two
statements. Antidepressants give a very modest benefit
over placebo. Whether this benefit is so modest as to not
be worth talking about depends on what level of benefits
you consider so modest as to not be worth talking about.
If you are as depressed as the average person who
participates in studies of antidepressants, you can expect
an antidepressant to have an over-placebo-benefit with an
effect size of 0.3 to 0.5. That's the equivalent of a diet
pill that gives you an average weight loss of 9 to 14
pounds, or a growth hormone that makes you grow on average
0.8 to 1.4 inches.
Note that this is the over-placebo benefit, and placebos already have a large benefit in most depression studies. |
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