[mveety]

> In the long term, cocaine use wrecks the mitochondia, which contributes to exhaustion. The proper therapy in this case is to restore the mitochondria density.

In mice, when given super high doses. The data for humans is much shakier and the effects of this are unknown, or if there are any, or if it even matters. AFAIK, none of the long term studies from reputable sources have shown long term effects on wakefulness or motivation past the initial withdrawal syndrome. This is just some new "meth neurotoxicity" hysteria bullshit to scare people into thinking drugs are bad.

[tcj_phx]

Going on my observations, cocaine is a much safer drug than meth amphetamine. She recovers quickly from cocaine, but it takes 3-4 days for her to recover from meth amphetamine use.

[mveety]

That doesn't have much to do with safety, more with half-life. Methamphetamine has a longer half-life (averages about 15 hours) than cocaine (about 5 minutes to an hour depending on route of administration). With long term regular use they both have problems. Methamphetamine can be neurotoxic in higher doses without the protection of tolerance and might cause Parkinson's disease later in life. Cocaine has circulatory effects long term, and if smoked causes damage to the lungs. With short term or occasional use they really aren't that bad for you in general (as is true with almost all drugs).