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by _98fj 3534 days ago
I know these things from a friend who is a doctor and works with these neurotransmitter tests since about 10 years.

I asked her how accurate these tests were and she said that, while you can't read everything off a sheet, there are patients, where she can already guess the result of the tests from the bodily symptoms the patient is describing (energy level at which times of the day, feeling of hunger, insomnia etc.).

Quite often serotonin is low and once it has been boosted (verified by an additional test a couple of month later) the patient is feeling a lot better.

Which, like I said, doesn't imply that that's all there is to mental well-being.

These tests also measure stress hormones, which usually are out of bounds as well.

> There is no evidence that SSRIs work by fixing a chemical imbalance.

I don't even know how one would define "chemical imbalance" in such a complex system as the human body.

All I know is that there are average ranges for transmitters and the more somebody's results are inside these ranges, the better he typically feels.

2 comments

There is no evidence for the chemical imbalance hypothesis. Your friend anecdotal evidence is contradicted by a large body of emprical research. For a good overview of the evidence on SSRIs on depression I would recommend the article "antidepressants and the placebo effect". https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/?report...
Balls I went deep on this one. Almost makes me want to subscribe to BJPsych or something. So interesting!
I think you should both stop here.
I don't. This sort of discussion from people in the field and what their friends see is helpful because it can change how other laypeople see the issue. Furthermore, I like seeing these sorts of discussions because I feel they make me more intelligent through gaining a different perspective.
I'm sorry - no text on Hacker News will convince me the person typing it is an expert in anything. Especially when they present inaccuracies and opinions as facts.
No way! Having MDs or MD like people on HN is a joy! We talk about the inanities of compsci jargon all the time on this site. Hearing the debates in Bio and the Medical field on here is a rare joy!