[throwawayIndian]

> how will "going nonprofit" be more motivating?

It may not!, but usually healing others is also self-healing.

One has to figure this path for themselves.

> I think you need to fix the depression issue first.

Absolutely! However, solving inability to work is equally important. Otherwise the patient will fall back into a depression again.

P.S: The comments above were for OP's inability to work, find work or be motivated about it. It isn't a solution for depression, which obviously needs thorough professional or medical help.