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by ThePhysicist 3548 days ago
I wonder how long it will take for the mosquitoes to evolve a mechanism that allows the female to detect males infected with that bacterium and not mate with them, or a mechanism to counteract the detrimental effect on the development of the eggs.

Right now the evolutionary pressure to do this is probably quite low as there is only a small number of infected males, but if that number goes up the pressure will increase exponentially.

Example:

If 1 % of males are currently infected with the bacteria, the selective advantage of a mosquito that can counteract the infection is just 1.0/0.99 (as the probability of mating with an infected male is just 1 percent), which is probably too small compared to other risks to produce any visible evolutionary effects.

If we increase the number of infected males to 90 %, the evolutionary advantage of detecting them soars to 1.0/0.1 = 10! This means a mosquito able to detect or counteract an infection is ten times as likely to produce offspring, which provides an incredibly strong gradient for evolution.

The question is of course how fast an immunity can arise (or if it already exists in the population), and how many generations of mosquitoes are able to survive after the infected males are introduced.

Probably they ran their own population genetics simulations on this, so I'd be curious to see results, which should give a good indication on whether this can work and if so under which conditions.

My personal guess is that it won't be effective, as there are very few cases where introducing a single external stress factor into a population causes it to collapse entirely, what's more likely is that it will adapt and relapse.

2 comments

Yes, it may be possible for the mosquito to fight back.

The bacteria isn't mentioned in the video, but I believe it could be Wolbachia, which is already pervalent in the insect world. According to this FAQ [1], it already infects 60% of the insect world, so it appears that developing an immunity to it might be pretty hard:

8. Do other animals carry Wolbachia?

Wolbachia is common among arthropods (including insects, spiders and other small animals with no backbone). Up to 60% of insect species naturally carry Wolbachia, including butterflies, dragonflies, moths and some mosquito species, but not the primary species of mosquito involved in the transmission of dengue.

Wolbachia is also found in certain types of roundworms – known as nematodes – but this is very different to the insect Wolbachia that we work with. Wolbachia is not found in any larger animals such as mammals, reptiles, birds and fish.

- [1] [ http://www.eliminatedengue.com/faqs/index/type/wolbachia ]

What are the effects of Wolbachia on other insects? Is there a risk that other insects get eliminated by eating mosquitos carrying Wolbachia? It may be safe for humans and larger mammals, but how about smaller animals ansd insects?
The Wolbachia bacteria is a parasite, but it spreads by infecting the reproductive organs of insects. I don't believe it can be spread by eating an insect infected with Wolbachia, unlike other kinds of parasites.
The website notes that it indeed is the Wolbachia bacteria.
The period with many less mosquitoes can still have a dramatic impact on future disease transmission. During the limited population period, the number of reservoir hosts also decreases dramatically (they either get over the illness or die). So later when the mosquito population rebounds, there is much less virus for them to spread.

For the diseases mentioned at the link there are animal hosts (other primates) so it won't be as effective, but for something like malaria where humans are the primary reservoir species, the effect can be very large.

It can also be effective in lowering the rates of transmission in urban areas.