Obviously the list goes on and on. If by "transcend" you really mean "ignore" or perhaps "aid those in trouble, leave the others alone" then, okay. But to eliminate the demand: I think the evidence, over many decades, many cultures, and despite billions (possibly trillions) of dollars of direct and indirect cost, the evidence speaks for itself.
Alcohol: nope.
Marijuana: nope.
Cocaine: nope.
Obviously the list goes on and on. If by "transcend" you really mean "ignore" or perhaps "aid those in trouble, leave the others alone" then, okay. But to eliminate the demand: I think the evidence, over many decades, many cultures, and despite billions (possibly trillions) of dollars of direct and indirect cost, the evidence speaks for itself.