| @ mchmch (dead response) > The Cause of Insulin Resistance What’s gumming up the door locks on our muscle cells, preventing insulin from letting glucose in? It’s fat. Intramyocellular lipids, or the fat inside our muscle cells. Yeah. There's something going on with fat. Majorly. I agree with that. And also, whatever it was that was making me crave carbohydrates also made me gain weight like crazy. And you know, when I went on a carb-free (<15g net carb) diet, my weight at the fastest was dropping by .54 lb/day . Yes. A day. I've also seen research, and talked with researchers who've also discovered that losing as little as 1g of fat on the pancreas can alleviate all symptoms of T2 diabetes. The problem, is there's no known way to target inter-organ fat. > Fat in the bloodstream can build up inside the muscle cell and create toxic fatty breakdown products and free radicals that can block the insulin signaling process. When that happens, no matter how much insulin we have in our blood, it won’t be able to open the glucose gates. That causes blood sugar levels to build up in the blood. Then why does doing a low/no carb diet cause us T2 diabetics along with prediabetics to lose weight on a massive scale? It seems to me that there's something wrong with the metabolics/genetics that do something funky to carbohydrates. Something like Carbohydrates -> sugar -> fat -> stored And it seems to short circuit what should normally just work. Source: The article linked in my previous comment. Yes there are sources cited. |