[vegabook]

I make extensive use of vectorization and use as many calls as I possibly can to the built-ins and/or c-based libraries. However as you well know, part of the fun in R is applying your own functions and unless you write these in C, you're back to native R and that's tediously slow. Ggplot another culprit -> amazing library, but if you're chucking out large amounts of custom charts with it it takes ages. Base graphics an order of magnitude faster (if less pretty and convenient for axis training).