As long as the founder(s) know what they're doing. I've seen way too many AI startups with founders who don't even have the most basic ML knowledge but are doing it because it's the trend.
Replace "ML knowledge" with "CS / SW Eng. knowledge" and I would say this has always existed in the start-up world. My personal opinion is that lack of basic technical knowledge is a major no-no unless at least one of the other co-founders is technical.