[projektfu]

So true. This is especially important as people study ways of improving metrics of markers of disease instead of actually improving disease endpoints. For example, there is a supplement marketed in the veterinary space that may lower blood urea nitrogen in uremic animals, according to a study. Whoop-de-do! I don't care about urea, it doesn't cause the disease of uremia. It is just a marker. You could convert all the urea to ammonia and now have a patient with two diseases and a BUN of 0.