[Frondo]

There's no reason why you couldn't have a male and female character acting out some zany scheme together, with the voice of reason provided by another male or female character.

Picking genders to be "the good ones" or "the bad ones" is lazy writing, no matter which side it ends up flattering.

[freehunter]

On the other hand, it was hilarious when Lisa was down because all the Simpsons were idiots and then it turned out that all the Simpson men were idiots but the women were quite successful. Very unexpected, which leads to great humor.