[throwaway729]

I'm afraid I don't quite understand what you mean by "achieves their targets by reducing the total burden of disease on humanity". Or maybe I just don't understand the difference between this as merely "achieves their targets by selling useful treatments to people"?

Could to elaborate?

[jaggederest]

A malaria vaccine would make no commercial sense but would be a huge reduction in the total burden of disease. That's what I mean.