I don't think so. Can a text editor do search and replace on a 100 GB file without a delay? You could construct an index, but that's not going to happen instantaneously either.
> Can a text editor do search and replace on a 100 GB file without a delay?
I meant that things like simply scrolling through a few pages or inserting/deleting a single character in the middle of the file shouldn't cause noticeable delays. Doing an operation that spans the entire file is different.