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by watermoose 3561 days ago
I've had ADD and slow executive function all of my life, along with a few other problems.

I was in denial or at least unsure about it for years. I'd had docs diagnose me with ADD, one who tested me extensively who though ADD was overdiagnosed that said I didn't have it, and had tried natural remedies, attempted to self-treat with caffeine- probably 5-12 cans of soda a day or several cups of coffee- and had a few really bad experiences and reactions with the meds that I tried.

Then I finally went to a psychiatrist that had been recommended to me by my doc and an friend of a friend and took GeneSight tests for genetic markers that indicate problems with different types of medications. I found one for ADD that was recommended and was prescribed that. It was Vyvanse which is amphetamine-based. It is lisdexamfetamine which is basically like a time-released dextroamphetamine. It becomes dextroamphetamine when the body cleaves off the lysine.

https://en.wikipedia.org/wiki/Lisdexamfetamine

https://en.wikipedia.org/wiki/Dextroamphetamine

I took Vyvanse and within an hour, I had a lot more energy and felt like I was "on". I didn't have any trouble focusing and it revved up my executive function so I was not thinking as slowly. I felt like it was going to solve all of my problems. However, even though I felt great and helped with some depression I was having also, I had some negative interactions at work. After getting "called into the office" after one of those, I knew I was going to have to do something else. Away from work, though, it was a great medication to be on, and since it was time-released, so I only had to take one in the morning. I still don't think it's a bad med.

I went back to the psychiatrist. She put me on Evekeo. It contains 50% levoamphetamine salts and 50% dextroamphetamine. On it, I can focus on what I'm doing like what I think a normal person does- or maybe better. I still will hear what others are saying and get distracted, but when I want to, and with help of music, I can really focus on my work. I can even focus more that I think that I could when I was younger and ADD wasn't affecting me as much. I still feel a little slower and am considering taking it and a smaller dose of dextroamphetamine. For me, it's a little like the real-world clear pill from Limitless.

I think eventually what I'd like to be on would be a combination of lisdexamfetamine and levoamphetamine (or a time-released version of it). It's possible that the L-lysine of lisdexamfetamine was also having some positive affects: https://www.drugs.com/npc/lysine.html

2 comments

The way you talk about it exactly mirrors my experience. I have ADD as well, and I take Adderal-XR. Without it I'm scattered, "double back" on my thoughts a lot, can't focus, and generally have no motivation.

With it I'm a different person. I can focus, I can finish a thought process, I'm motivated, things become clear. I can actually "keep up" with others in "normal life", and it makes me a great programmer.

It really does feel like the magic pill from limitless.

Now, I tried alternatives when I was younger, and none really worked that well. Vyvanse put me to sleep, concerta (sp?) Didn't work at all. adderal-xr worked, but the "come down" sucks, it ruins my appetite, and its almost impossible to get around here (every place never has it).

I'm afraid to start trying others as I feel entirely useless without my medicine, and I know that because of the legal issues around these drugs, trying one out but keeping my backup of my old medicine is not going to fly. So I just deal with it.

    > Vyvanse put me to sleep, adderal-xr worked, but the "come down" sucks
Adderall does have a bad come down. Often depressive even on low XR doses.

Vyvanse is still amphetamine, so if it put you to sleep, are you sure you took enough?

20mg Adderall XR is about equivalent to 50mg Vyvanse, which is what I take.

Everyone I know switched from Adderall to Vyvanse and we all report the same thing -- much more gradual curve throughout the day and far less depressive on the come down. I'd consider Adderall XR to be a real tweak compared to Vyvanse and far less therapeutic for a day-to-day drug.

I may be mixing them up, I was around 15 when I last "experimented" with the different drugs.

I might talk to my doctor about my options next time I'm in there. The comedown doesnt bother me all that much, but I think it is starting to bother my wife as I can get a bit "cranky".

Have you talked to your doctor about Zenzedi? It is manufactured by Arbor Pharma like Evekeo