[dekhn]

I doubt you could avoid diffusion in these proteins to the point you desire. It would be worth looking into species that exploit cryptobiosis, specifically anhydrobiosis (rotifers, tardigrades, daphnia, and C. Elegans are all examples). In most cases they can dessicate extremely, some of them by exchanging glucose or water with trehalose (itself a fascinating topic worth further study), so i wonder if you could make trehalose binding sites inside the body.