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by dx4100 3583 days ago
I spent years on the self-medication supplement train. I still take Vitamin D and a few other modest supplements, but I finally got REAL relief after just biting the bullet and trying nearly every anti-depressant under the sun. After a few, my doctor did a DNA test to determine gene-drug interaction because of the wild results I was having. Thankfully, this was covered under my insurance. It shed a lot of light on why many of the pills I had taken failed -- the test showed they're likely to have bad reactions based on my genes.

We used the information to choose Viibyrd, a fairly new anti-depressant (2011). I've kind of become an evangelist for it since.

It works like a traditional SSRI but also affects the 5-HT1A receptors. Another great feature of the medication is that it usually takes less than a week to notice results -- and results I noticed.

I've been plagued with anxiety since age 18 and depression since I was a kid. For the first time in 11 years, I'm anxiety free. For the first time in a long time, I'm nearly depression free.

The best part? I'm myself. I'm not dull. I'm not a zombie. Some of my other impulsivity and ADHD symptoms vanished. I'm way more productive, social, and less afraid to take on life.

It was fun and interesting to do the whole supplement stack, but ultimately a huge time and money waster. I spent far less time going to my Psychiatrist and trying different options to get REAL results.

I feel like in many ways Nootropic supplements are the Homeopathy for Nerds -- we're using cutting edge research to anecdotally try to fix our issues, and ignoring that even we're just as susceptible to the placebo effect as the rest of the population.

Here's a good read that's sort of on topic about the stigma of medication and mental illness:

https://themighty.com/2016/02/myths-about-mental-illness-med...

1 comments

What you should become an evangelist for is doing the gene testing (to get further insight/clarity into potential interactions and issues) you mention.

In my case, I was forced to seek traditional help, but that didn't work for me, which lead me to looking into alternatives. I researched for a long time, then came across (and had better luck with) many of the supplements and nootropics in the stacks I link to.

That is, I'm not saying to use this as an excuse to avoid traditional routes; it's more that many either have tried such routes only to see no real improvement, or want to quickly give off-the-shelf options a try before becoming "a part of the system." Not everyone is a fan of prescription anti-anxiety, antidepressant, or antipsychotic medication (or their side effects, especially).

> Not everyone is a fan of prescription anti-anxiety, antidepressant, or antipsychotic medication (or their side effects, especially).

Lots of people go along with the "professional's" prescription, not knowing that these drugs are known to not work very well. They're only used because the professionals think that "they're the best we have at present time," (paraphrasing Harriet Hall MD's quote from skeptic magazine). The thinking is that if the first drugs don't work, they can always "try, try again".

Benzodiazepines are great for anxiety, until they stop working after about 4 weeks. Then you're just addicted to them to keep from spiraling down into an anxious hell.

SSRI's are the epitome of corporate science. Someone came up with the serotonin-deficiency theory of depression, Wall Street came up with a drug to sell, poof everyone got switched from anti-serotonin antidepressants to the new pro-serotonin patent drugs. There are some negative articles about Prozac in the Boston Globe's archives circa-2000, but their exposé wasn't enough to stop the juggernaut. There is now a page somewhere on Wikipedia that talks about why the SSRI's actually work for a small percentage of the people who take it... More often than not, SSRI's have a tendency to ruin people. Lexapro helped my girlfriend relapse, years ago.

"Anti-psychotics" were originally sold as tranquilizers. These drugs are given to difficult patients so that the system can pretend it's helping people, but really these bad drugs make the patient more psychotic over time. Most psychotic patients recover with time and/or sobriety.

See my comment history for references.

Many studies have shown 5-HTP is about as effective as SSRIs for depression and OCD. Memantine has also been shown in studies to work well for OCD (and sometimes even depression or anxiety), and that's mainly because it's an uncompetitive NMDA antagonist first, then an Alzheimer's treatment option (as it has been pigeonholed into being).