[mturmon]

Besides consumables like fuel, mentioned nearby, there are also mechanical parts like gyroscopes or reaction wheels (https://en.m.wikipedia.org/wiki/Reaction_wheel) which maintain pointing. If the s/c contains an imager, there will probably be a mechanical shutter, protective cover, and/or filter wheel.

There can also be higher power electronics, like signal amplifiers or radios, which tend to fail more often than computer electronics. Finally, there is cumulative radiation damage, and the possibility that a combination of single event upsets can get the s/c into an unrecoverable state.

From time to time, operational changes can force the s/c into new operating modes ("we need to flip the camera to take images to fit a new point spread function"). These new operating modes can cause unforeseen consequences ("when flipped, the antenna has to be pointed differently to target the ground station") that ripple through the system. As the mission wears on, the chance of a new operating condition tickling a latent problem increases, because there are a lot more latent problems.