[dekhn]

It's nice there are more gene editing methods but this just moves the problem back where it always belonged: delivery of the vector to the cells that matter, and knowing what edit to make are still extremely hard problems. The latter seems to be the ultimate challenge: our current understanding of genomics is still very much stuck in the "the function of a gene is assumed to be the largest eigenvalue of its principle component analysis". In complex, redundant systems with feedback (like the genome and its associated cellular machinery) it's basically impossible to fix an actual problem, with limited side effects, by just modifying a single gene.