I have been using the Kinesis Freestyle on my Mac with the VIP accessory pads and it is very comfortable. I place the two parts of the keyboard on the sides of my 15" MBP.
I have the Freestyle 2 (which I reviewed here [0]) and it's great. My wrists are so much more relaxed. Every time I have to use a traditional keyboard now I cringe. It's also helped me improve touch-typing.
Unfortunately, I have not found a good solution for a mice. The Magic Trackpad, even turned around in negative slope, is just not good enough when there's a bit too much drag&drop.
I absolutely loved the RollerMouse before I got my Kinesis Advantage. It might work for the Freestyle though so you could consider giving it a try. Still the most ergonomic mouse I've used to date.
I use a Wacom for some tasks, but I find it even worse than a mouse if you are switching back and forth a lot. For drag and drop I recommend the Contour Design Rollermouse Red. The downside is it doesn't pair well with a deep keyboard, as it wants to replace any wrist rest.
Unfortunately, I have not found a good solution for a mice. The Magic Trackpad, even turned around in negative slope, is just not good enough when there's a bit too much drag&drop.
[0] http://blog.pythonaro.com/2015/01/kinesis-freestyle2-multich...