[dominotw]

I am no way qualified to interpret or make any sense those. 23andme has been in existence for over a decade, sure these papers might be great but have they led to anything tangible that a ordinary person like me can benefit from ? I am genuinely curious, i really want to know.

I've been a subscriber for over 7 yrs and have gotten all the upgrades they offered over the years. I am yet to get a single useful peice of data out of it. All my extended family has it too and none of them have gotten anything out of it other than of entertainment value. If they have made significant breakthroughs why I am as a consumer not seeing any benefits in over a decade.

[nibs]

I (correctly) self diagnosed (later confirmed by gastroenterologist) my Celiac disease through 23andme. But that is the easiest 1:1 gene correlation out there. My friend found out he had the same Parkinsons gene as Sergey Brin, and there are potentially things you can do to prepare. Exome testing may or may not be useful, depending on how much you invest in analyzing the results. I think it was of limited value until I ran it through Promethease.

[dekhn]

I don't know anybody in the field who thinks that 23andme, on its own or in collaborations, has made any truly signficant scientific contributions. I haven't read all their papers, but I've read some, and have talked to their scientists extensively, and I really haven't heard of anything that is strikingly important that could be solely attributed to 23andme.

Their relative finder feature seems to work pretty well.