Not sure about hotkeys. Current Twitter and Github hijack enough well known bindings that it got annoying. So, what hotkeys would Electron allow that wouldn't work in a generic browser?
I meant global system-wide hotkeys that work even when the application is not focused, not JavaScript-event-based page hotkeys. In the stable (Qt-based) Skype for example I bind Ctrl+Alt+PgUp to answer a call, and Ctrl+Alt+PgDown to stop the call.